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Relationship Between Its Presence and the Occurrence of a Destructive Process in the Brains of Encephalitic Patients

Claude Jacque, PhD; Annick Delassalle, PhD; Gerald Rancurel, MD; Monique Raoul; Bruno Lesourd, MD; Jean-Claude Legrand, MD

Arch Neurol. 1982;39(9):557-560.

Abstract
• Serum and CSF levels of myelin basic protein (MBP) were measured in 50 patients with encephalitis of various origins and severity. In nearly 50%, the CSF samples were found to display immunoreactivity to MBP. Positivity was found to be correlated with the severity of the clinical signs. More precisely, it corresponded to cases with suspected extensive brain destruction. No relationship could be observed with the cause of disease. Positive tests of sera were infrequent, even from patients whose CSF was rich in MBP. Longitudinal studies performed on 20 patients who were serially investigated during periods ranging from three weeks to 18 months demonstrated that after an attack, MBP liberation into the CSF persists for one to three weeks. The MBP assay should serve as an index for destruction of nervous tissue.

Author Affiliations
From the Laboratoire de Neurochimie (Dr Jacque and Ms Raoul) and the Clinique Neurologique (Drs Rancurel and Lesourd), Hôpital de la Salpêtrière, and the Service de Biochimie Médicale, Faculté de Médecine Pitié-Salpêtrière (Drs Delassalle and Legrand), Paris.

Footnotes
Accepted for publication Sept 1, 1981.

Reprint requests to Laboratoire de Neurochimie, INSERM U.134, CNRS ERA 421, Hôpital de la Salpêtrière, 75651 Paris Cedex 13, France (Dr Jacque).

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