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Follow-up of 57 Patients From Five to 41 Years and a Profile of 14 Patients With Permanent Severe Visual Loss

James J. Corbett, MD; Peter J. Savino, MD; H. Stanley Thompson, MD; Tulay Kansu, MD; Norman J. Schatz, MD; Linda S. Orr, MD; Daniel Hopson, MD

Arch Neurol. 1982;39(8):461-474.

Abstract
• The prognosis for vision in most patients with pseudotumor cerebri is excellent; however, visual loss, which is the only serious complication, may occur either early or late in the course of the disease. A group of 57 patients was followed up five to 41 years with visual fields, visual acuity, and fundus photographs. Blinding visual loss or severe visual impairment in one or both eyes occurred in 14 patients, and in seven patients, this occurred months to years after the initial symptoms. Systemic hypertension was a significant risk factor for visual loss in patients with pseudotumor cerebri, and blindness occurred in eight of 13 patients who were hypertensive. Despite suggestions that blind spot measurement is useful for following up patients with this condition, we believe that sequential quantitative perimetry gives more complete information and is essential to rational decision making in the treatment of pseudotumor cerebri.

Author Affiliations
From the Neuroophthalmology Unit, Wills Eye Hospital, Philadelphia (Drs Corbett, Savino, Kansu, Schatz, and Orr), and the Neuroophthalmology Unit, University of Iowa, Iowa City (Drs Corbett, Thompson, and Hopson).

Footnotes
Accepted for publication Sept 13, 1981.

Reprint requests to Department of Neurology, University of Iowa Hospitals, Iowa City, IA 52242 (Dr Corbett).

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