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Acetylcholine Receptor Antibody Production

Marjorie E. Seybold, MD; Constantine Tsoukas, PhD; Jon Lindstrom, PhD; Sherman Fong, PhD; John Vaughan, MD

Arch Neurol. 1982;39(7):433-435.

Abstract
• Acetylcholine receptor antibody (AChR-ab) and IgG were studied in vivo and in vitro in a patient with myasthenia gravis, who was undergoing multiple leukoplasmaphereses. In this patient, leukoplasmapheresis accelerated production of AChR-ab and total IgG as would be expected if antibody acted through feedback as an inhibitor of its own synthesis. Cells capable of suppressing AChR-ab production were demonstrated before and after leukoplasmapheresis, indicating that AChR-ab production in this patient was not the result of detectable loss of suppressor-cell activity.

Author Affiliations
From the Veterans Administration Medical Center and University of California, San Diego (Dr Seybold); Scripps Clinic and Research Foundation, La Jolla, Calif (Drs Tsoukas, Fong, and Vaughan); and Salk Institute for Biological Studies, San Diego (Dr Lindstrom).

Footnotes
Accepted for publication Sept 15, 1981.

Reprint requests to San Diego Veterans Administration Medical Center, 3350 La Jolla Village Dr, San Diego, CA 92161 (Dr Seybold).

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ABSTRACT