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Rapid Efficacy of Alfacalcidol

Dolores Mateo, MD; Santiago Giménez-Roldán, MD

Arch Neurol. 1982;39(7):424-425.

Abstract
• A man with a three-year history of profound dementia and convulsions was found to have idiopathic hypoparathyroidism. Twenty-four hours after the oral administration of alfacalcidol (1-hydroxycholecalciferol), a virtually complete restoration of mental function was seen. Normal plasma calcium levels were only achieved after six weeks of therapy. It is suggested that reversion of a metabolically blocked neuronal state could take place rapidly through activation of calcium-cell receptors by alfacalcidol-promoted rising ionic calcium levels.

Author Affiliations
From the Department of Neurology, Hospital Provincial de Madrid.

Footnotes
Accepted for publication Sept 8, 1981.

Reprint requests to Department of Neurology, Hospital Provincial de Madrid, Doctor Esquerdo 46, Madrid-30, Spain (Dr Mateo).

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