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A Quantitative Study

Justin A. Zivin, MD, PhD; Umberto DeGirolami, MD; Elliott L. Hurwitz, MD

Arch Neurol. 1982;39(7):408-412.

Abstract
• The sequence of events in focal cerebral ischemia has been difficult to study quantitatively in humans. Experimental investigation of these phenomena has been impeded because reproducible animal models that simulate human stroke are lacking. We have developed a rabbit spinal cord ischemia model that resembles human stroke patterns in many respects. Using this model, we have found that (1) brief ischemia produces completely reversible neurological deficits; (2) intermediate ischemic periods may produce transiently reversible deficits that later progress without further manipulation; (3) prolonged ischemia produces irreversible lesions in all animals. The model should be useful for studies of the pathophysiological mechanisms of CNS ischemia.

Author Affiliations
From the Departments of Neurology (Drs Zivin and Hurwitz) and Pathology (Neuropathology) (Dr DeGirolami), University of Massachusetts, Worcester.

Footnotes
Accepted for publication Oct 18, 1981.

Read in part before the Tenth Annual Meeting of the Society for Neuroscience, Cincinnati, Nov 14, 1980.

Reprint requests to Department of Neurology, 55 Lake Ave N, Worcester, MA 01605 (Dr Zivin).

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