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Diagnosis by Semithin Plastic-Embedded Sections of Peripheral Blood Lymphocytes From a Patient With a Normal Blood Smear

Richard G. Curless, MD; Joseph C. Parker, Jr, MD; John T. Flynn, MD

Arch Neurol. 1982;39(5):308-310.

Abstract
• Neuronal ceroid lipofuscinosis is an important diagnostic consideration in a school-aged child with progressive blindness. Neurologic symptoms and signs may appear late, and the retinopathy is not specific. Ultrastructural abnormalities have been demonstrated in many body tissues, but skin has been claimed to be the most reliable. Light and electron microscopic examinations of WBCs have also been helpful in several instances. In the case reported, the skin biopsy specimen and light microscopy of a peripheral blood buffy coat failed to disclose diagnostic changes. Examination of semithin sections of plastic-embedded peripheral blood provided the answer.

Author Affiliations
From the Departments of Neurology (Dr Curless), Pathology (Dr Parker), and Ophthalmology (Dr Flynn), University of Miami School of Medicine.

Footnotes
Accepted for publication June 29, 1981.

Presented in part as a poster presentation at the 105th meeting of the American Neurological Association, Boston, Sept 9, 1980.

Reprint requests to PO Box 016960, Department of Neurology, University of Miami School of Medicine, Miami, FL 33101 (Dr Curless).

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ABSTRACT