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Harry Bartfeld, MD; Marilyn S. Pollack, PhD; Susanna Cunningham-Rundles, PhD; Hyman Donnenfeld, MD

Arch Neurol. 1982;39(5):270-271.

Abstract
• Our study of the distribution of HLA-A, -B, and -C in patients with amyotrophic lateral sclerosis (ALS) found no statistically significant deviation. We found a trend, however, toward a decrease in HLA-A9, as we had reported previously, and toward an increase in HLA-Bw35 and -Cw4. The worldwide incidence of ALS is uniform except in Guam and on Japan's Kii peninsula, and published reports from many countries, including Guam, show no consistent deviation in HLA frequencies related to ALS.

Author Affiliations
From the Amyotrophic Lateral Sclerosis Research Center, St Vincent's Hospital and Medical Center of New York (Drs Bartfeld and Donnenfeld) and the Tissue Typing Laboratory (Dr Pollack) and Clinical Immunology Laboratory (Dr Cunningham-Rundles), Memorial Sloan-Kettering Cancer Center, New York.

Footnotes
Accepted for publication July 15, 1981.

Reprint requests to Amyotrophic Lateral Sclerosis Research Center, St Vincent's Hospital and Medical Center, 153 W 11th St, New York, NY 10011 (Dr Bartfeld).

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ABSTRACT