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Progressive Isolated Segmental Anhidrosis
Alan I. Faden, MD;
Philip Chan, MD;
Edward Mendoza, MD
Arch Neurol. 1982;39(3):172-175.
Abstract
• A patient had progressive segmental anhidrosis, which proved after extensive neurologic and autonomic workup to be an isolated abnormality. Intradermal acetylcholine produced localized sweating in areas of thermoregulatory anhidrosis five months after the onset of symptoms but failed to do so at two years. These findings are consistent with a preganglionic sympathetic lesion affecting a functionally defined subset of sympathetic cells and/or fibers. The alteration of the sudomotor response to intradermal acetylcholine during the course of the illness suggests that the diagnostic utility of pharmacologic sweat tests may be time dependent, limited to a relatively early period following onset of anhidrosis.
Author Affiliations
From the Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Md (Dr Faden); the Department of Dermatology, Tripler Army Medical Center, Honolulu (Dr Chan); and the Department of Neurology, Eisenhower Army Medical Center, Augusta, Ga (Dr Mendoza).
Footnotes
Accepted for publication Feb 28, 1981.
Reprint requests to Department of Neurology, Room 1036, Bldg A, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 (Dr Faden).
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