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Regular Involvement of Clarke's Nucleus in Sporadic Amyotrophic Lateral Sclerosis
Paul Averback, MD;
Paul Crocker
Arch Neurol. 1982;39(3):155-156.
Abstract
• Morphometric study of Clarke's nucleus in 12 cases of sporadic amyotrophic lateral sclerosis and 12 normal control subjects showed an average 36% reduction in the neuronal population in the disease group, with involvement in each case. Histopathologic findings of cell degeneration were definite but less noticeable than in the ventral horns. The process seems likely to be similar to that affecting motor neurons but is less advanced at the time of death.
Author Affiliations
From the Department of Pathology, University of Cambridge, England. Dr Averback is now with McGill University, Montreal.
Footnotes
Accepted for publication Aug 1, 1980.
Reprint requests to Department of Pathology, McGill University, Pathology Institute, 3775 University St, Montreal, Quebec, Canada H3A 2B4 (Dr Averback).
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