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Effect of Naloxone on the 'On-Off' Syndrome in Patients Receiving Long-term Levodopa Therapy
Marco Trabucchi, MD;
Sirio Bassi, MD;
Lodovico Frattola, MD
Arch Neurol. 1982;39(2):120-121.
Abstract
• Naloxone hydrochloride, an opiate antagonist, was given to six parkinsonian patients suffering from the "on-off" phenomenon. Although the drug does not modify the cardinal symptoms of parkinsonism, it reduces dyskinetic movements and the length of the rigid phase. There may be an interaction of opiate receptors with the different neurotransmitter systems involved in the on-off syndrome.
Author Affiliations
From the Departments of Pharmacology (Dr Trabucchi) and Neurology (Drs Bassi and Frattola), University of Milan (Italy).
Footnotes
Accepted for publication March 24, 1981.
Reprint requests to Ospedale Bassini, Via Gorki 50, 20092, Cinisello Balsamo, Italy (Dr Frattola).
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