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II. Immunohistochemical Studies

Leena Peltonen, MD, PhD; Raili Myllylä, PhD; Uolevi Tolonen, MD, PhD; Vilho V. Myllylä, MD, PhD

Arch Neurol. 1982;39(12):756-759.

Abstract
• Immunofluorescence studies using specific antibodies against collagen of types I, III, IV, and V were carried out on muscle biopsy specimens from 22 patients with various neuromuscular disorders and seven controls. Increased staining with all antibodies was seen in the patients with polymyositis and muscular dystrophy. Increased staining with types I and III antibodies was found in the samples from the patients with amyotrophic lateral sclerosis in cases with an elevated concentration of muscular hydroxyproline. Two patients with amyotrophic lateral sclerosis showed no accumulation of collagen, and this was similarly true of the polyneuropathy cases. An accumulation of types IV and V collagen was typical for the myotonia congenita samples. The immunohistochemical results were in good agreement with the biochemical findings from the same patients.

Author Affiliations
From the Departments of Medical Biochemistry (Dr R. Myllylä), Anatomy (Dr Peltonen), and Neurology (Drs Tolonen and V. Myllylä), University of Oulu, Oulu, Finland.

Footnotes
Accepted for publication Feb 25, 1982.

Reprint requests to Department of Medical Biochemistry, University of Oulu, SF-90220 Oulu 22, Finland (Dr R. Myllylä).

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