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Endocrine Evaluation

Thomas M. Jones, MD; Riley Yu, PhD; Jack P. Antel, MD

Arch Neurol. 1982;39(11):721-722.

Abstract
• Four men with amyotrophic lateral sclerosis (ALS) were treated with 200 mg of intramuscular testosterone weekly. Endocrine evaluation, using a gonadotropin-releasing hormone infusion test, indicated the expected degree of suppression of pituitary luteinizing hormone and follicle-stimulating hormone production. These data suggest that testosterone's (androgen) interaction with its receptors in the hypothalamic-pituitary axis is normal in patients with ALS.

Author Affiliations
From the Department of Neurology (Drs Yu and Antel) and Medicine (Dr Jones), University of Chicago.

Footnotes
Accepted for publication Dec 11, 1981.

Reprint requests to Department of Neurology, University of Chicago, 950 E 59th St, Chicago, IL 60637 (Dr Antel).