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Neurotoxic Effects of Cisplatin Therapy
Thomas J. Walsh, MD;
Arthur W. Clark, MD;
Irma M. Parhad, MD;
William R. Green, MD
Arch Neurol. 1982;39(11):719-720.
Abstract
• Swelling of the optic disc and loss of tendon reflexes developed in a 31/2-yearold girl after 11 high-dose courses of cisplatin (cis-dichlorodiammine platinum [II]) therapy for recurrent sacrococcygeal teratoma. Postmortem examination demonstrated optic disc swelling; the spinal cord showed loss of myelinated fibers and gliosis of the dorsal columns. To our knowledge this case is the first in which the neuropathologic changes associated with cisplatin therapy have been demonstrated by postmortem examination.
Author Affiliations
From the Departments of Pathology (Drs Walsh, Clark, and Parhad), Neurology (Drs Clark and Parhad), and Ophthalmology (Dr Green), Johns Hopkins University School of Medicine, Baltimore. Dr Walsh is now with Michael Reese Hospital and Medical Center, Chicago
Footnotes
Accepted for publication Dec 23, 1981.
Reprint requests to 509 Pathology Bldg, The Johns Hopkins Hospital, Baltimore, MD 21205 (Dr Clark).
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