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Marker Proteins of Platelet Activation in Patients With Cerebrovascular Disease
Marc Fisher, MD;
Peter H. Levine, MD;
Albert L. Fullerton, MD;
Ann Forsberg, MA;
Celeste P. Duffy, MA;
James J. Hoogasian;
David A. Drachman, MD
Arch Neurol. 1982;39(11):692-695.
Abstract
• Platelet activation is assumed to occur in many patients with strokes or transient ischemic attacks (TIAs). Determination of this activity can now be measured by assaying the platelet-specific proteins, platelet factor 4 and β-thromboglobulin. These proteins are platelet specific and are released during irreversible aggregation. The plasma level of these proteins was measured in patients with strokes and TIAs and both groups had significantly greater values than healthy control subjects. These markers of platelet activation may provide further understanding of the role of platelets in the etiology, diagnosis, and treatment of cerebrovascular disease.
Author Affiliations
From the Department of Neurology (Drs Fisher, Fullerton, and Drachman), University of Massachusetts Medical School; the Division of Neurology, St Vincent Hospital (Dr Fullerton); the Blood Research Laboratory and Department of Medicine, Memorial Hospital (Dr Levine, Mss Forsberg and Duffy, and Mr Hoogasian); and the Department of Medicine, University of Massachusetts Medical Center (Dr Levine, Mss Forsberg and Duffy, and Mr Hoogasian), Worcester.
Footnotes
Accepted for publication Dec 8, 1981.
Reprint requests to Department of Neurology, University of Massachusetts Medical Center, 55 Lake Ave N, Worcester, MA 01605 (Dr Fisher).
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