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Jerzy Hildebrand, MD; Marianne Malarme, MD; Jacqueline Flament-Durand, MD; Pierre Stryckmans, MD

Arch Neurol. 1982;39(10):664-665.

Abstract
• A 39-year-old man died of acute nonlymphoblastic leukemia (ANLL). At age 35, he had undergone an operation for a frontal astrocytoma (grade 4), and received a 6,000-rad cranial irradiation, followed by intensive chemotherapy combining teniposide (VM-26) plus lomustine and 2,4-diamino-5-4'-dichlorophenyl-6-methylpyrimidine (DDMP). This new case of ANLL occurring as a second neoplasm in a patient previously treated for a malignant brain tumor is considered to be related to the antineoplastic therapy.

Author Affiliations
From the Department of Neurology, Hôpital Erasme (Dr Hildebrand); the Department of Internal Medicine, Institut Jules Bordet (Drs Malarme and Stryckmans); and the Department of Neuropathology, University of Brussels (Dr Flament-Durand); Brussels.

Footnotes
Accepted for publication Jan 6, 1982.

Reprint requests to Department of Neurology, Hôpital Erasme, 808, route de Lennick, 1070 Brussels, Belgium (Dr Hildebrand).

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