 |
|
Prevalence of Psychosis in Epilepsy as a Function of the Laterality of the Epileptogenic Lesion
Ira Sherwin, MD;
Pierre Peron-Magnan, MD;
Jean Bancaud, MD;
Alain Bonis, MD;
Jean Talairach, MD
Arch Neurol. 1982;39(10):621-625.
Abstract
• Retrospective analysis of the psychiatric diagnoses in a group of patients surgically relieved of medically intractable epilepsy tested the hypothesis that patients with left-sided temporal lobe epileptogenic lesions are at greater risk for the development of a so-called schizophrenic-like psychosis than are those with right-sided temporal lobe epileptogenic lesions. The data confirmed the hypothesis and also demonstrated an increased prevalence of sinistrals in the psychotic group. Thus, epilepsy involving the dominant hemisphere at the inception of the seizure disorder is the significant risk factor. The data also indicated that a psychosis is unlikely to develop in patients with other (nontemporal) forms of focal epilepsy. On the basis of these data and data from other studies, the prevalence of psychosis in patients with poorly controlled temporal lobe epilepsy was estimated to be approximately 10% to 15%.
Author Affiliations
From the Epilepsy Research (INSERM) Unit-97 (Drs Peron-Magnan, Bancaud, and Bonis) and the Special Functional Neurosurgery Service (Dr Talairach), Saint Anne's Hospital, Paris, the Edith Nourse Rogers Memorial Veterans Administration Hospital, Bedford, Mass (Dr Sherwin), and the Department of Neurology, Harvard Medical School, Boston (Dr Sherwin).
Footnotes
Accepted for publication Nov 2, 1981.
Read in part at the 25th annual meeting of the American Epilepsy Society, San Diego, Nov 21, 1980.
Reprint requests to Bedford Veterans Administration Hospital, Bedford, MA 01730 (Dr Sherwin).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Psychiatric Classification of Nonconversion Nonepileptic Seizures
Jacobs and Herzog
Arch Neurol 1995;52:1044-1045.
ABSTRACT
Prolactin: Quo Vadis?
Herzog
Arch Neurol 1992;49:223-224.
ABSTRACT
Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy
Sloviter
Science 1987;235:73-76.
ABSTRACT
|
