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Influence of Blood Pressure, Osmolarity, and Blood-Brain Barrier Damage

K. Gwan Go, MD; Adriaan A. Lammertsma, MSc; Anne M. J. Paans, MSc; Willem Vaalburg, PhD; Martien G. Woldring, PhD

Arch Neurol. 1981;38(9):581-584.

Abstract
• By external detection, the influence of arterial blood pressure (BP), osmolarity, and cold-induced blood-brain barrier damage was assessed on the extraction of water labeled with oxygen 15 during single-capillary transit in the rat. There was an inverse relation between arterial BP and extraction that was attributable to the influence of arterial BP on cerebral blood flow (CBF) and the relation between CBF and extraction. Neither arterial BP nor osmolarity of the injected bolus had any direct effect on extraction of water¹⁵O, signifying that the diffusional exchange component (determined by blood flow) of extraction greatly surpasses the convection flow contribution by hydrostatic or osmotic forces. Damage to the blood-brain barrier did not change its permeability to water.

Author Affiliations
From the Departments of Neurosurgery (Dr Go) and Nuclear Medicine (Ms Paans and Drs Vaalburg and Woldring), University of Groningen, the Netherlands. Dr Lammertsma is a Fellow of the Stichting Koningin Wilhelmina Fonds.

Footnotes
Accepted for publication Nov 20, 1980.

Reprint requests to Department of Neurosurgery, University Hospital Groningen, Oostersingel 59, Groningen 9700 RB, the Netherlands (Dr Go).

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