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Association With Alzheimer's Disease

Peter Blumbergs, MB, BS, FRACP, FRCPA; Roy Beran, MB, BS, FRACGP; Paul Hicks, MB, BS, FRACP, MRCP

Arch Neurol. 1981;38(7):453-454.

Abstract
• Myoclonus and progressive intellectual deterioration developed in a 46-yearold woman with trisomy 21 (Down's syndrome) during the final stages of her illness. Her condition was clinically diagnosed as Creutzfeldt-Jakob disease, but necropsy demonstrated the changes characteristic of Alzheimer's disease and cerebrovascular amyloidosis.

Author Affiliations
From the Division of Tissue Pathology (Neuropathology), Institute of Medical and Veterinary Science (Dr Blumbergs), Adelaide; and the Department of Neurology, Queen Elizabeth Hospital (Drs Beran and Hicks), Woodville, South Australia.

Footnotes
Accepted for publication Jan 15, 1981.

Reprint requests to Division of Tissue Pathology (Neuropathology), Institute of Medical and Veterinary Science, Box 14, Rundle Street Post Office, Adelaide, South Australia 5000 (Dr Blumbergs).

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Myoclonus in Down's Syndrome: Treatment With Clonazepam
Good and Howard
Arch Neurol 1982;39:195-195.
ABSTRACT