You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 38 No. 7, July 1981 TABLE OF CONTENTS
  Archives
  •  Online Features
  ORIGINAL ARTICLES
 This Article
 •References
 •Full text PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Neurotransmitter Abnormalities in Patients With Motor Neuron Disease

Krystyna Belendiuk, PhD; George W. Belendiuk, MD, PhD; Daniel X. Freedman, MD; Jack P. Antel, MD

Arch Neurol. 1981;38(7):415-417.


Abstract

• In 22 patients with motor neuron disease (MND), the mean concentration of serotonin (5HT) in platelets was slightly increased, platelet monoamine oxidase (MAO) activity was significantly increased, and plasma concentrations of total and both free and bound tryptophan were significantly decreased. Though platelet MAO activity was positively correlated with concentrations of 5HT, independent causal mechanisms are probable. When patients were rated according to severity, highest values of platelet 5HT and MAO activity were found in the most severely affected group, whereas concentrations of both total and protein-bound tryptophan were most decreased. Changes in concentrations of 5HT and tryptophan may reflect compensatory changes in response to degeneration of motor neurons or to interruption of their monoaminergic innervation.



Author Affiliations

From the Departments of Psychiatry and Neurology, The University of Chicago.


Footnotes

Accepted for publication Oct 31, 1980.

Reprint requests to Department of Psychiatry, University of Chicago, 950 E 59th St, Chicago, IL 60637 (Dr Freedman).



THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The psychopharmacology of autism and related disorders
Gillberg
J Psychopharmacol 1996;10:54-63.
 





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1981 American Medical Association. All Rights Reserved.