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John T. Callaghan, MD; James I. Ausman, MD, PhD; Robert Clubb, MD, PhD

Arch Neurol. 1981;38(6):390-391.

Abstract
• A shunt infection and meningitis developed in a patient receiving methotrexate intravenously for CNS leukemia. Convulsions and respiratory failure followed the intraventricular administration of 300,000 units of penicillin G potassium. Perfusion with 900 mL of Ringer's lactate removed an amount of penicillin equal to that injected intraventricularly plus some from systemic treatment.

Author Affiliations
From Veterans Administration Hospital, Minneapolis (Dr Callaghan); Department of Neurological Surgery and Neurology, Henry Ford Hospital, Detroit (Dr Ausman); and Department of Neurosurgery, National Naval Medical Center, Bethesda, Md (Dr Clubb). Dr Callaghan is now at Lilly Laboratory for Clinical Research, Indianapolis.

Footnotes
Accepted for publication Aug 14, 1980.

Reprint requests to Lilly Research Laboratories, Division of Eli Lilly and Co, PO Box 618, Indianapolis, IN 46206 (Dr Callaghan).

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