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Model of Wernicke's Encephalopathy
Juan C. Troncoso, MD;
Michael V. Johnston, MD;
Kathryn M. Hess;
John W. Griffin, MD;
Donald L. Price, MD
Arch Neurol. 1981;38(6):350-354.
Abstract
• After a week on a thiamine-free diet and daily injections of pyrithiamine hydrobromide, a group of rats began to lose weight; soon thereafter hypothermia, piloerection, and ataxia developed, followed by convulsions and death. Neuropathologic examination disclosed hemorrhagic necrotic lesions in the thalamus, hypothalamus, collicular plate, vestibular nuclei, and inferior olives. The control groups did not show neurologic signs or neuropathologic abnormalities. The lesions in thiamine-deficient rats were similar in character and distribution to those of human Wernicke's disease. Because this experimental regimen produces neuropathologic changes rapidly and consistently, this animal model should be useful in studies designed to examine the pathophysiologic aspects of experimental Wernicke's disease in particular and CNS thiamine deficiency in general.
Author Affiliations
From the Division of Neuropathology, Departments of Pathology (Drs Troncoso and Price) and Neurology (Drs Troncoso, Johnston, Griffin, and Price and Ms Hess), The Johns Hopkins University School of Medicine, Baltimore.
Footnotes
Accepted for publication Sept 18, 1980.
Reprint requests to Division of Neuropathology, The Johns Hopkins Hospital, Baltimore, MD 21205 (Dr Troncoso).
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