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Quantitative Histologic and Immunofluorescent Studies

Marcelino G. Reyes, MD; Jared J. Gardner, MD; Jack D. Poland, MD; Thomas P. Monath, MD

Arch Neurol. 1981;38(6):329-334.

Abstract
• Using techniques of stereology, we measured the severity of lesions in ten cases of acute St Louis encephalitis (SLE) from the 1975 epidemic in northern Illinois. Percentage of fractional volume and numerical profile density on area (N/A) of cellular nodules and N/A of blood vessels with perivascular inflammatory cellular infiltration were significantly correlated in 17 anatomic regions of the CNS. Ranking of the severity of lesions in these regions agreed with subjective estimates of other cases of SLE. Immunofluorescent tests established the presence of SLE viral antigen in cell bodies of neurons. Our findings contribute to better understanding of the pathology of SLE in man.

Author Affiliations
From the Department of Pathology, Division of Neuropathology, Mount Sinai Hospital, Chicago (Dr Reyes); the Viral Immunology Branch, Centers for Disease Control, Atlanta (Dr Gardner); and the Vector Borne Disease Division, Centers for Disease Control, Fort Collins, Colo (Drs Poland and Monath).

Footnotes
Accepted for publication Sept 18, 1980.

Read in part before the joint annual meeting of the College of American Pathologists-American Society of Clinical Pathologists, Atlanta, March 25, 1980.

Reprint requests to Department of Pathology, Mount Sinai Hospital, Chicago, IL 60608 (Dr Reyes).

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