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Investigation With 31P Nuclear Magnetic Resonance Spectroscopy

Gunseli Sarpel, MD; Harry J. Lubansky, PhD; Moris J. Danon, MD; Akira Omachi, PhD

Arch Neurol. 1981;38(5):271-274.

Abstract
• Phosphorus 31 nuclear magnetic resonance (³¹P NMR) signals were recorded from intact human erythrocytes for 16 hours. Total phosphate concentration, which was estimated as the sum of the individual³¹P signals, was 25% lower in erythrocytes from men with myotonic dystrophy than in control erythrocytes. The inorganic-phosphate fraction contained the highest average phosphate concentration over the 16-hour period, and made the major contribution to the difference in total phosphate between the two groups. This result was not observed in erythrocytes from either women with myotonic dystrophy or patients with Duchenne's dystrophy and may be due to a change in cell membrane permeability to inorganic phosphate, which leads to lower steadystate concentrations of the intracellular phosphates.

Author Affiliations
From the Departments of Neurology (Drs Sarpel and Danon) and Physiology and Biophysics (Drs Lubansky and Omachi), University of Illinois Medical Center, and the Department of Neurology (Dr Sarpel), Veterans Administration West Side Medical Center, Chicago.

Footnotes
Accepted for publication July 5, 1980.

Reprint requests to Department of Neurology, 912 S Wood St, Chicago, IL 60612 (Dr Sarpel).

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