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Lesions of the Nucleus Ansae Peduncularis in Neuropsychiatric Disease
Paul Averback, MD
Arch Neurol. 1981;38(4):230-235.
Abstract
• The nucleus of the ansa peduncularis in the substantia innominata frequently contains degenerating neurons in patients with Huntington's disease, Alzheimer's disease, schizophrenia, and possibly other neurological and neuropsychiatric conditions. A large number of the degenerating cells are found only exceptionally in neurologically normal patients who are without mental symptoms, and the significance of the lesion may be related to quantitative factors, analogous to granulovacuolar degeneration of the hippocampus. The cells show massive distention with solvent-extractable lipid-pigment vacuolar droplet material that imparts a distinctive light and electron microscopic appearance.
Author Affiliations
From the Department of Pathology, University of Cambridge, Cambridge, England. Dr Averback is currently with the Department of Pathology, McGill University, Montreal.
Footnotes
Accepted for publication Aug 19, 1980.
Reprint requests to 3775 University St, Montreal, PQ, Canada H3A 2B4 (Dr Averback).
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