This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Association With Mechanical Injuries

Kiyotaro Kondo, MD; Tadao Tsubaki, MD

Arch Neurol. 1981;38(4):220-226.

Abstract
• Two case-control studies of motor neuron disease that involved 712 cases and 158 cases, respectively, showed that (1) mechanical injuries were two to three times more frequent in both sexes, heralding amyotrophic lateral sclerosis, progressive bulbar paralysis, and progressive muscular atrophy; (2) the head, neck, spine, and the extremities were more often traumatized; (3) traumatized parts were not correlated with the initial manifestation of the disease; and (4) more males were traumatized, but males still predominated among uninjured cases. These results suggested that mechanical injuries were not the cause, but probably one of the risk factors of the disease. No association was observed with smoking, drinking, residence, home space, drinking water, animals, experience as a war prisoner, stay on Guam, parental consanguinity, measles, polio, mumps, tuberculosis, rheumatism, prothesis of the total teeth, shell splinters retained in the body, occupational exposures to radiations, chemicals, or gases, atomic bombings, electric injuries, surgical operations, and occupations.

Author Affiliations
From the Department of Neurology, Brain Research Institute, Niigata University, Japan.

Footnotes
Accepted for publication May 15, 1980.

Reprint requests to the Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan 951 (Dr Kondo).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Head Injury and Amyotrophic Lateral Sclerosis
Chen et al.
Am J Epidemiol 2007;166:810-816.
ABSTRACT | FULL TEXT  

Solvent neurotoxicity.
Dick
Occup. Environ. Med. 2006;63:221-6, 179.
FULL TEXT  

A cause for concern?
McCrory
Br. J. Sports. Med. 2005;39:249-249.
FULL TEXT  

Prospective Study of Cigarette Smoking and Amyotrophic Lateral Sclerosis
Weisskopf et al.
Am J Epidemiol 2004;160:26-33.
ABSTRACT | FULL TEXT  

Amyotrophic Lateral Sclerosis, Heterogeneous Susceptibility, Trauma, and Epidemiology
Riggs
Arch Neurol 1996;53:225-227.
ABSTRACT  

Amyotrophic Lateral Sclerosis: Recent Advances in Pathogenesis and Therapeutic Trials
Mitsumoto et al.
Arch Neurol 1988;45:189-202.
ABSTRACT  

Trauma and Amyotrophic Lateral Sclerosis
Riggs
Arch Neurol 1985;42:205-205.
ABSTRACT  

A New Hypothesis of the Etiology of Amyotrophic Lateral Sclerosis: The DNA Hypothesis
Bradley and Krasin
Arch Neurol 1982;39:677-680.
ABSTRACT