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David L. Madden, DVM, PhD; William C. Wallen, PhD; Sidney A. Houff, MD; Pauli A. Leinikki, MD; John L. Sever, MD, PhD; Katherine A. Holmes, PhD; Gabriel A. Castellano, PhD; Isabel C. Shekarchi, PhD

Arch Neurol. 1981;38(4):209-210.

Abstract
• Sera from patients with multiple sclerosis and carefully matched controls were tested for antibodies to three strains of coronavirus. There was no significant difference in the levels of antibody in the patients vs the controls. We conclude that unless the strains of coronaviruses recently reported to have been isolated from patients with multiple sclerosis express important serological differences from those used in these studies, coronaviruses are not associated with the cause of multiple sclerosis.

Author Affiliations
From the Infectious Diseases Branch, National Institute of Neurological and Communicative Disorders and Stroke (Drs Madden, Wallen, Houff, Leinikki, and Sever); the Department of Pathology, Uniformed Services University of the Health Sciences (Dr Holmes); and Microbiological Associates (Drs Castellano and Shekarchi), Bethesda, Md.

Footnotes
Accepted for publication June 20, 1980.

Presented in part at the first international Herti Foundation Meeting, Frankfort, West Germany, Sept 10-12, 1979.

Reprint requests to National Institutes of Health, Bldg 36, Room 5D06, Bethesda, MD 20205 (Dr Madden).

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ABSTRACT