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D. Frank Benson, MD; Donald T. Stuss, PhD; Margaret A. Naeser, PhD; William S. Weir, MD; Edith F. Kaplan, PhD; Harvey L. Levine, MD

Arch Neurol. 1981;38(3):165-169.

Abstract
• To explore the long-term effects of bilateral prefrontal destruction, 16 schizophrenics who had undergone prefrontal leukotomy approximately 25 years earlier were studied by neurologic examination, psychiatric outcome, EEG, computerized tomography (CT), and a battery of neuropsychological tests. Five nonleukotomized chronic schizophrenics and five agematched normal subjects served as controls. We report details on the subjects, outline the test procedures, and offer an overview of the long-term residua. In general, the larger the frontal lesion demonstrated by CT, particularly if asymmetric, the better the psychiatric outcome and the better the performance on psychological testing, but there was no correlation between frontal lesion size and either neurologic or EEG abnormality.

Author Affiliations
From the Departments of Neurology (Dr Benson), Psychology (Drs Stuss, Naeser, and Kaplan), and Radiology (Dr Levine), Boston Veterans Administration Medical Center; and the Department of Neurology (Dr Weir), Northhampton (Mass) VA Medical Center.

Footnotes
Accepted for publication June 14, 1980.

Reprint requests to Neurology Department, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90024 (Dr Benson).

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