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H. Lassmann, MD; H. Budka, MD; G. Schnaberth, MD

Arch Neurol. 1981;38(2):99-102.

Abstract
• A case of multiple sclerosis (MS) occurred in which there were recent demyelinated plaques in the CNS, and inflammatory demyelination and remyelination in the peripheral (Schwann cell) portions of the spinal roots. The lesions in the peripheral nervous system (PNS) were characterized by inflammation, primary segmental demyelination, myelin stripping, the occurrence of lipid debriscontaining macrophages in the endoneurium, and remyelination. To our knowledge, this is the first description of simultaneous acute inflammatory demyelination in the CNS and PNS in MS.

Author Affiliations
From the Neurological Institute (Drs Lassmann and Budka) and the Neurological Clinic (Dr Schnaberth), University of Vienna.

Footnotes
Accepted for publication May 24, 1980.

Reprint requests to Neurological Institute, University of Vienna, Schwarzspanierstrasse 17, A-1090 Vienna, Austria (Dr Lassmann).

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