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Report of a Case

John J. Halperin, MD; Edward P. Richardson, Jr, MD; Jay Ellis, MD; Jeffrey S. Ross, MD; Shirley H. Wray, MD

Arch Neurol. 1981;38(12):773-775.

Abstract
• A 47-year-old woman displayed rapidly worsening cerebellar degeneration, bulbar encephalitis, and peripheral neuropathy four years after radical mastectomy and a course of systemic chemotherapy for breast cancer. Progressive neurologic deterioration over a period of one year ended with her death from intercurrent infection. Postmortem examination failed to reveal any recurrent neoplasm, but neuropathologic study revealed cerebellar degeneration and bulbar encephalitis consistent with paraneoplastic disease.

Author Affiliations
From the Department of Neurology, Massachusetts General Hospital, Boston (Drs Halperin, Richardson, and Wray), and the Departments of Neurology (Dr Ellis) and Pathology (Dr Ross), Berkshire Medical Center, University of Massachusetts, Pittsfield, Mass.

Footnotes
Accepted for publication April 13, 1981.

Reprint requests to Department of Neurology, Massachusetts General Hospital, Boston, MA 02114 (Dr Halperin).

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ABSTRACT