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Study With Two-Dimensionaln Electrophoresis

Moris J. Danon, MD; Carol S. Giometti, PhD; Jose R. Manaligod, MD, PhD; Osvaldo H. Perurena, MD; John L. Skosey, MD, PhD

Arch Neurol. 1981;38(12):761-766.

Abstract
• A 65-year-old woman with progressive muscle weakness and a diffuse rash of three years' duration was examined. Muscle tissue was studied with histochemical techniques, phase-contrast microscopy, electron microscopy, and twodimensional electrophoresis. Histochemical studies showed numerous nemaline rods, with a normal ratio of types I and II fibers. Two-dimensional electrophoresis revealed abnormalities in the myosin light chain and tropomyosin protein patterns when compared with normal and diseased muscle biopsy samples, including those from two patients with adult-onset dermatomyositis.

Author Affiliations
From the Departments of Neurology (Drs Danon and Perurena), Pathology (Drs Danon and Manaligod), and Medicine (Dr Skosey), University of Illinois Medical Center, Chicago; and the Molecular Anatomy Program, Argonne (Ill) National Laboratory (Dr Giometti).

Footnotes
Accepted for publication March 16, 1981.

Reprint requests to University of Illinois Medical Center, Neurology Department, 912 S Wood St, Chicago, IL 60612 (Dr Danon).

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