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Encephalopathy in Infants and Children With Chronic Renal Disease
Catherine M. Foley, MD;
Martin S. Polinsky, MD;
Alan B. Gruskin, MD;
H. Jorge Baluarte, MD;
Warren D. Grover, MD
Arch Neurol. 1981;38(10):656-658.
Abstract
• The examination of five pediatric patients with encephalopathy secondary to chronic renal failure has indicated a stereotyped sequence of neurologic signs and symptoms including ataxia, loss of motor abilities, myoclonus, seizures, dementia, and bulbar dysfunction. Both the patients with CNS dysfunction and a control group selected for a similar degree of renal failure had increased levels of serum phosphate, alkaline phosphatase, and parathyroid hormone. Serial EEGs in the affected group revealed progressive slowing and an increase in paroxysmal features. No specific neuropathologic findings were noted in one patient.
Author Affiliations
From the Sections of Child Neurology (Drs Foley and Grover) and Renology (Drs Polinsky, Gruskin, and Baluarte), Department of Pediatrics, St Christopher's Hospital for Children; and the Department of Neurology (Drs Foley and Grover), Temple University School of Medicine, Philadelphia.
Footnotes
Accepted for publication Jan 28, 1981.
Read in part before the Child Neurology Society, Charlottesville, Va, Oct 6, 1977.
Reprint requests to 2600 N Lawrence St, Philadelphia, PA 19133 (Dr Grover).
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ABSTRACT
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