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Effect of CSF on Bacterial Growth
Melanie M. Agbayani, MD;
Judith Braun;
Chia T. Chang, MD;
Leonard Glass, MD;
Hugh E. Evans, MD
Arch Neurol. 1981;38(1):43-45.
Abstract
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• The growth patterns of five potentially pathogenic bacteria (Staphylococcus aureus, Escherichia coli, Listeria monocytogenes, group B β-hemolytic streptococcus, and Klebsiella pneumoniae) and a commonly encountered, nonpathogenic microorganism (S epidermidis) were compared using CSF, trypticase soy broth (TSB), and a phosphate buffer. Each grew less in CSF than in TSB. Escherichia coli was least affected, with a median difference of 2 logarithms between CSF and TSB at 24 hours of growth, whereas S epidermidis was markedly inhibited, with a median difference of 6.85 logarithms. The differences among the remaining four organisms ranged from 3.86 to 5.94 logarithms, all significantly greater than that for E coli. Similar results were obtained at 48 hours of growth. The nonsupport of bacterial growth by CSF may constitute a host defense mechanism. The basis of these observations may be the presence of inhibitors or the absence of nutrients required for bacterial growth in the CSF.
Author Affiliations
From the Department of Pediatrics, Jewish Hospital and Medical Center of Brooklyn, State University of New York-Downstate Medical Center, Brooklyn.
Footnotes
Accepted for publication April 5, 1980.
Read in part before the 78th annual meeting of the American Society for Microbiology, Las Vegas, May 16, 1980.
Reprint requests to Department of Pediatrics, Jewish Hospital and Medical Center of Brooklyn, 555 Prospect Pl, Brooklyn, NY 11238 (Dr Evans).
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