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Measles and Canine Distemper AntibodyPresence in Sera From Patients With Multiple Sclerosis and Matched Control Subjects
David L. Madden, DVM, PhD;
William C. Wallen, PhD;
Sidney A. Houff, MD;
Isabel C. Shekarchi, PhD;
Pauli O. Leinikki, MD, PhD;
Gabriel A. Castellano, PhD;
John L. Sever, MD, PhD
Arch Neurol. 1981;38(1):13-15.
Abstract
• Antibody to measles virus and canine distemper virus (CDV) was demonstrated in sera from patients with multiple sclerosis (MS) and from carefully matched control subjects. Elevated measles and CDV antibody titers were found in patients with MS when compared with the matched control subjects. The correlation between the measles and CDV antibody titers was quite high, suggesting that the antibody levels between the two viruses are very closely related. Based on the results of our study and a review of the literature, our conclusion is that the CDV antibody levels in patients with MS and matched control subjects are associated with occurrence of measles virus antibodies.
Author Affiliations
From the Infectious Diseases Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health (Drs Madden, Wallen, Houff, Leinikki, and Sever); and Microbiological Associates (Drs Shekarchi and Castellano), Bethesda, Md.
Footnotes
Accepted for publication April 23, 1980.
Read in part before the First International Herti Foundation Meeting, Frankfurt, West Germany, Sept 12, 1979.
Reprint requests to Infectious Diseases Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bldg 36, Room 5 D-06 (National Institutes of Health), Bethesda, MD 20205 (Dr Madden).
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