This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (6)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Barbara A. Neilan, MD; Ilo E. Leppik, MD

Arch Neurol. 1980;37(9):580-581.

Abstract
• Phenytoin sodium has been associated with the formation of altered T lymphocyte rosettes in vitro. To investigate the clinical relevance of this observation, the formation of T lymphocyte rosettes in nine patients was studied before treatment with phenytoin and after therapeutic concentrations of the drug in plasma were attained. The percentage of total rosette-forming cells found before treatment was not significantly different from the percentage found 24 hours after treatment. Likewise, the percentage of active rosette-forming cells before phenytoin therapy was not significantly less than after therapy. These results suggest that in vivo treatment with phenytoin does not acutely inhibit the formation of T lymphocyte rosettes.

Author Affiliations
From the Departments of Medicine (Dr Neilan) and Neurology (Dr Leppik), University of Minnesota Medical School, Minneapolis. Dr Neilan is now with Temple University Hospital, Philadelphia.

Footnotes
Accepted for publication Oct 14, 1979.

Reprint requests to Department of Medicine, Temple University Hospital, 3401 N Broad St, Philadelphia, PA 19140 (Dr Neilan).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?