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Janis M. Peyser, PhD; Keith R. Edwards, MD; Charles M. Poser, MD; Susan B. Filskov, PhD

Arch Neurol. 1980;37(9):577-579.

Abstract
• The performance of patients with multiple sclerosis on selected psychological tests was examined to ascertain the usefulness of such examinations to diagnosis. Cognitive impairment was studied in relationship to disease-related factors, physician's identification of cerebral involvement, and psychological adjustment. The results indicate that half the subjects exhibited cognitive impairment. Levels of neurologic involvement, physical impairment, and depression were not predictive of cognitive impairment. Of the subjects who were judged on neurological examination to have intact mentation, half were actually impaired. Impaired cognitive functioning, which is often not detected through routine examination, may occur early in the disease. These deficits may represent manifestations of otherwise undetectable plaques in the subcortical white matter.

Author Affiliations
From the Section of Medical Psychology, Department of Psychiatry (Dr Peyser), and the Department of Neurology (Drs Edwards and Poser), College of Medicine, University of Vermont, Burlington; and the Department of Psychology, University of South Florida, Tampa (Dr Filskov).

Footnotes
Accepted for publication Nov 13, 1979.

Reprint requests to Medical Psychology, Medical Center Hospital of Vermont, Burlington, VT 05401 (Dr Peyser).

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