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Lithium Carbonate Therapy for Cluster HeadacheChanges in Number of Platelets, and Serotonin and Histamine Levels
Jose L. Medina, MD;
Jewed Fareed, PhD;
Seymour Diamond, MD
Arch Neurol. 1980;37(9):559-563.
Abstract
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• Three groups of patients were studied: Group A consisted of 12 patients with cluster headache that was treated with lithium carbonate. Group B consisted of six patients with cluster headache that was managed with other drugs. Group C consisted of five patients with muscle contraction headache who received lithium. Serum lithium levels, platelet count, platelet serotonin levels, and platelet-rich plasma histamine levels were determined before and during therapy. The frequency of the headache and levels of serotonin and histamine tended to follow a parallel course in groups A and B: as the headache frequency dropped, serotonin and histamine levels fell. The stable period was characterized by little change in serotonin and histamine levels. Recurrences of headaches were accompanied by a return of serotonin and histamine to pretreatment levels. The course of cluster headache is related to changes in serotonin and histamine levels. Lithium, by modifying the headache course, changes serotonin and histamine levels.
Author Affiliations
From Diamond Headache Clinic, Ltd, Chicago (Drs Medina and Diamond), Department of Pathology and Pharmacology, Loyola University of Chicago (Dr Fareed), Neurology Service, Hines Veterans Administration Hospital, Hines, Ill (Dr Medina), and the Chicago Medical School, Chicago (Dr Diamond).
Footnotes
Accepted for publication Oct 8, 1979.
Reprint requests to Diamond Headache Clinic, Ltd, 5252 N Western Ave, Chicago, IL 60625 (Dr Medina).
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