This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (48)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Case Reports and Review of the Literature

Reynaldo P. Lazaro, MD; Howard S. Kirshner, MD

Arch Neurol. 1980;37(9):555-558.

Abstract
• Weakness of the proximal muscle groups developed in six uremic patients, five men and one woman, while receiving hemodialysis. All showed roentgenographic evidence of renal osteodystrophy. Partial to complete recovery of strength followed subtotal parathyroidectomy in four patients. All patients had normal levels of creatine phosphokinase. Electrodiagnostic testing showed features of both "myopathic" and denervating processes on coaxial needle exploration and normal to slowed nerve conduction. Muscle biopsy specimens in four patients showed type 2 fiber atrophy with no evidence of necrosis, phagocytosis, regeneration, or vasculitis. The pathogenesis of proximal muscle weakness in uremia is uncertain but may be related to secondary hyperparathyroidism or osteodystrophy.

Author Affiliations
From the Department of Neurology, Vanderbilt University School of Medicine, Nashville, Tenn. Dr Lazaro is now at Wayne County General Hospital, Westland, Mich.

Footnotes
Accepted for publication Oct 27, 1979.

Reprint requests to Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN 37232 (Dr Kirshner).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Meta-analysis: Vitamin D Compounds in Chronic Kidney Disease
Palmer et al.
ANN INTERN MED 2007;147:840-853.
ABSTRACT | FULL TEXT  

Sevelamer: a promising but unproven drug
Palmer et al.
Nephrol Dial Transplant 2007;22:2742-2745.
FULL TEXT  

Vitamin D status and muscle strength
McCarty
Am. J. Clin. Nutr. 2002;76:1454-1455.
FULL TEXT  

Cardiac Troponin T and Creatine Kinase MB Content in Skeletal Muscle of the Uremic Rat
Fredericks et al.
Clin. Chem. 2002;48:859-868.
ABSTRACT | FULL TEXT  

Low-Protein Diet Improves Muscle Energy Metabolism in Chronic Renal Failure
Aquilani et al.
Nutr Clin Pract 1997;12:266-273.
ABSTRACT