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Role of Alcohol Withdrawal and Anoxic Encephalopathy

Nai-Shin Chu, MD

Arch Neurol. 1980;37(9):551-554.

Abstract
• Periodic lateralized epileptiform discharges (PLEDs) occurred in three patients during alcohol withdrawal, in two patients with episodes of anoxic ischemia, and in one patient under both conditions. In contrast to previous observations that PLEDs are often associated with acute gross destructive lesions, autopsy results and neurological studies reported here indicated that alcohol withdrawal and/or anoxic ischemia may activate preexisting focal hemispheric lesions to produce PLEDs.

Author Affiliations
From the Department of Neurology, University of California at Irvine Medical Center, Orange, Calif.

Footnotes
Accepted for publication Sept 17, 1979.

Reprint requests to Department of Neurology, University of California at Irvine Medical Center, 101 City Drive South, Orange, CA 92668 (Dr Chu).

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