Periodic Lateralized Epileptiform Discharges With Preexisting Focal Brain Lesions: Role of Alcohol Withdrawal and Anoxic Encephalopathy

doi:10.1001/archneur.1980.00500580047006

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Vol. 37 No. 9, September 1980

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Periodic Lateralized Epileptiform Discharges With Preexisting Focal Brain Lesions

Role of Alcohol Withdrawal and Anoxic Encephalopathy

Nai-Shin Chu, MD

Arch Neurol. 1980;37(9):551-554.

Abstract

• Periodic lateralized epileptiform discharges (PLEDs)occurred in three patients during alcohol withdrawal, in twopatients with episodes of anoxic ischemia, and in one patientunder both conditions. In contrast to previous observationsthat PLEDs are often associated with acute gross destructivelesions, autopsy results and neurological studies reported hereindicated that alcohol withdrawal and/or anoxic ischemia mayactivate preexisting focal hemispheric lesions to produce PLEDs.

Author Affiliations

From the Department of Neurology, University of California at Irvine Medical Center, Orange, Calif.

Footnotes

Accepted for publication Sept 17, 1979.

Reprint requests to Department of Neurology, University of Californiaat Irvine Medical Center, 101 City Drive South, Orange, CA 92668(Dr Chu).

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