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Their Association in an American-Jewish Ethnic Group

Teresita S. Elizan, MD; Paul I. Terasaki, PhD; Melvin D. Yahr, MD

Arch Neurol. 1980;37(9):542-544.

Abstract
• Eighteen unrelated American-Jewish patients of Eastern European extraction who had classical postencephalitic Parkinson's disease were typed for HLA-A, HLA-B, and HLA-C antigenic determinants. Compared with 147 ethnically matched controls, the HLA-B14 antigen showed a highly significantly increased frequency in the postencephalitic Parkinson's group (corrected P =.001). This association, though not necessarily reflecting genetic susceptibility to the disease, strongly suggests such a possibility in the pathogenesis of at least this particular variant of parkinsonism.

Author Affiliations
From the Department of Neurology, The Mount Sinai School of Medicine of the City University of New York (Drs Elizan and Yahr), and the Department of Surgery, Tissue Typing Laboratory, UCLA School of Medicine, Los Angeles (Dr Terasaki).

Footnotes
Accepted for publication March 25, 1980.

Reprint requests to Department of Neurology, The Mount Sinai School of Medicine, 1 Gustave L. Levy Pl, New York, NY 10029 (Dr Elizan).

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