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Vincenzo Silani, MD; Guglielmo Scarlato, MD; Giorgio Valli, MD; Maurizio Marconi, MD

Arch Neurol. 1980;37(8):511-513.

Abstract
• The effectiveness of plasma exchange in amyotrophic lateral sclerosis (ALS) was tested in four patients. Electromyography (EMG) and clinical examinations were carried out before, during, and after the treatment. The EMG data showed a progressive unaffected motor neuronal decay. Clinically the course of the disease was not dissimilar to that usually encountered, although a momentary improvement was observed in two patients after the first procedure. Plasma exchange appears to be of no value in treating ALS.

Author Affiliations
From the Department of Neurology, Medical School, University of Milan (Drs Silani, Scarlato, and Valli), and the Transplantation Immunology and Blood Transfusion Service, the Ospedale Maggiore Policlinico, Milan (Dr Marconi). Dr Silani is now with the Department of Neurology, Baylor College of Medicine, Texas Medical Center, Houston.

Footnotes
Accepted for publication Aug 31, 1979.

Reprint requests to Department of Neurology, Baylor College of Medicine, Texas Medical Center, Houston, TX 77030 (Dr Silani).

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