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Immunofluorescent Demonstration of Simian Virus 40 Antigen in CSF Cells and Response to Cytarabine Therapy

A. C. Boudewijn Peters, MD; Jan Versteeg, MD; Gerard T. A. M. Bots, MD; Willem Boogerd, MD; G. Jan Vielvoye, MD

Arch Neurol. 1980;37(8):497-501.

Abstract
• We report an instance of progressive multifocal leukoencephalopathy in which cytarabine administration was successful as demonstrated by clinical course and follow-up computerized tomography studies. In this case, simian virus 40 (SV40) antigen was demonstrated in CSF cells by the indirect immunofluorescence technique.

Author Affiliations
From the Departments of Neurology (Drs Peters and Boogerd), Neuropathology (Dr Bots), Neuroradiology (Dr Vielvoye), and the Laboratory of Medical Microbiology (Dr Versteeg), University Hospital, Leiden, The Netherlands.

Footnotes
Accepted for publication Aug 22, 1979.

Reprint requests to Department of Neurology, University Hospital, Leiden, The Netherlands (Dr Peters).

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