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A Quantitative Study

P. J. Delwaide, MD; A. Hurlet, MD

Arch Neurol. 1980;37(7):441-443.

Abstract
• Eight women with senile dementia and buccolinguofacial dyskinesias (BLFD) were given bromocriptine mesylate (from 2.5 to 20.0 mg daily). The frequency of their abnormal movements was quantitated by a method consisting of repeated counts (220 measurements per patient). In six patients, the mean frequency of BLFD was lower during bromocriptine mesylate therapy (even at daily doses of 10 mg or less) as compared with placebo; this result was statistically significant in four of the six. The second day after cessation of bromocriptine therapy, there seemed to be a rebound effect in six patients. These phenomena are discussed in light of the possible existence of presynaptic "autoreceptors" that would explain the paradoxical effects produced by a number of dopamine agonists.

Author Affiliations
From the Section of Neurology-Clinical Neurophysiology, Department of Internal Medicine, University of Liège, Liège, Belgium.

Footnotes
Accepted for publication Aug 6, 1979.

Reprint requests to Institut de Medicine, Hopital de Baviére, Bd de la Constitution 66, 4020 Liège, Belgium (Dr Delwaide).

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