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Report of a Fatal Case With Neuropathological Observations

Keiji Ichikawa, MD; R. C. Kim, MD; Harry Givelber, MD; George H. Collins, MD

Arch Neurol. 1980;37(7):429-432.

Abstract
• In a 23-year-old primigravida with no prior history of rheumatic fever, chorei-form movements developed late in the third trimester, and she died in a state of hyperthermia 14 days later. Results of neuropathological examination showed, as the basis for the chorea, nerve cell loss and astrocytosis within the striatum (especially the caudate nucleus). Analysis of the case in conjunction with a review of the literature strongly suggests that chorea gravidarum should be regarded as a syndrome rather than a specific disease entity.

Author Affiliations
From the Department of Pathology, State University of New York, Syracuse (Drs Ichikawa, Kim, and Collins), and the Department of Pathology, Geneva General Hospital, Geneva, NY (Dr Givelber). Dr Ichikawa is currently with the Department of Internal Medicine, Hyogo Prefectural Hospital, Hyogo, Japan.

Footnotes
Accepted for publication July 17, 1979.

Reprint requests to Department of Pathology, State University of New York, Upstate Medical Center, Syracuse, NY 13210 (Dr Kim).

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