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Fumie Yamaguchi, MD; John S. Meyer, MD; Masahiro Yamamoto, MD; Fumihiko Sakai, MD; Terry Shaw, PhD

Arch Neurol. 1980;37(7):410-418.

Abstract
• Regional cerebral blood flow measured in patients with dementias (N = 60) using xenon Xe 133 inhalation was compared with measurements in healthy volunteers (N = 70). Volunteers were age-matched (N = 15); another group was younger. In normal aging, there is progressive, diffuse reduction of weight and flow of gray matter (F₁) but not of white matter. Therefore, age-matched control subjects are necessary in studies of dementia. In Alzheimer's disease (AD), F₁ shows bilateral and symmetrical reduction. The F₁ reduction correlated with atrophy estimated by computerized tomography, and duration and severity of dementia. In multi-infarct dementia (MID), bilateral hemispheric F₁ was patchily reduced. Cerebral vasodilator response to 5% carbon dioxide inhalation was reduced in patients with MID but was normal in patients with AD. Patients with Wernicke-Korsakoff's dementia showed normal values. Patients with dementia due to multiple sclerosis showed significant F₁ reduction compared with normal subjects. Standard behavioral activation in all patients with moderate to severe dementia failed to produce normal F₁ increases.

Author Affiliations
From the Department of Neurology, Baylor College of Medicine, the Baylor Center for Cerebrovascular Research, and the Cerebral Blood Flow Laboratory, Veterans Administration Medical Center, Houston.

Footnotes
Accepted for publication April 24, 1979.

Reprint requests to Veterans Administration Medical Center, 2002 Holcombe Blvd, Houston, TX 77211 (Dr Meyer).

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