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Alfredo Feria-Velasco, MD, MS; Norma Olivares, Chem; Fernando Rivas, MD; Marcos Velasco, MD; Francisco Velasco, MD

Arch Neurol. 1980;37(5):287-290.

Abstract
• Thickness and cellularity of motor cortical layers adjacent to epileptogenic lesions produced by administration of alumina cream (AC) were measured in the brains of 18 cats that were at latent, convulsive, and remissive stages of an experimental model of epilepsy. Shamoperated animals were used as controls. Brains were fixed by perfusion and embedded in paraffin. Sections of motor cortex adjacent to the AC deposit were obtained at constant thickness to measure thickness and cellularity in each cortical layer. A statistically significant reduction in thickness and cellularity was detected in layers 2, 4, and 6, whereas reduction in these aspects was not significant in layers 3 and 5 in the initial stages of the model (latent and convulsive). It is suggested that AC may exert a cytotoxic effect on inhibitory neurons located at layers 2 and 4, to determine an imbalance of intracortical excitability.

Author Affiliations
From the Division of Developmental Biology, Unidad de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara (Drs Feria-Velasco, Olivares, and Rivas), and Section of Neurology, Unidad de Investigación del Centro Médico Nacional (Drs Velasco and Velasco), Mexico.

Footnotes
Accepted for publication June 5, 1979.

Reprint requests to Apartado Postal 1-3838, Guadalajara, Jalisco, Mexico (Dr Feria-Velasco).

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