CSF Antibody to Myelin Basic Protein: Measurement in Patients With Multiple Sclerosis and Subacute Sclerosing Panencephalitis

doi:10.1001/archneur.1980.00500530044005

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Vol. 37 No. 4, April 1980

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CSF Antibody to Myelin Basic Protein

Measurement in Patients With Multiple Sclerosis and Subacute Sclerosing Panencephalitis

Hillel S. Panitch, MD; Carol J. Hooper; Kenneth P. Johnson, MD

Arch Neurol. 1980;37(4):206-209.

Abstract

• A solid phase radioimmunoassay was used to detect antibodiesto myelin basic protein (MBP) in the CSF of patients with multiplesclerosis (MS) and subacute sclerosing panencephalitis (SSPE).F(ab')₂ fragments prepared from SSPE IgG retained their activity,which showed that the assay measures a true antigenantibodyreaction rather than nonspecific adherence of IgG to MBP. Samplesof CSF from 48 patients with MS and 30 patients with SSPE weretested and, in both conditions, antibody activity was significantlygreater than in controls, when tested at identical IgG concentrations.In MS, levels of antibody were highest in patients with acuteexacerbations and lower in patients in remission, which supportedthe hypothesis that autoimmunity to a myelin antigen may playa role in the pathogenesis of the disease. The reaction withMBP was consistently more pronounced in SSPE than in MS. Inview of the association of SSPE with measles virus and the presenceof high titers of measles antibody in the CSF, antibodies tomeasles and to MBP may be directed against similar antigenicdeterminants.

Author Affiliations

From the Department of Neurology, University of California, and Veterans Administration Medical Center, San Francisco.

Footnotes

Accepted for publication Aug 31, 1979.

Reprint requests to Neurology (127), Veterans AdministrationMedical Center, 4150 Clement St, San Francisco, CA 94121 (DrPanitch).

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