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Periodic Alternating Nystagmus in Phenytoin Intoxication
William W. Campbell, Jr, MD
Arch Neurol. 1980;37(3):178-180.
Abstract
A patient with alcoholic cerebellar degeneration had periodic alternating nystagmus during a period of phenytoin intoxication. The nystagmus resolved as the serum phenytoin level fell, as demonstrated by electronystagmography. Periodic alternating nystagmus generally implies structural brainstem disease, especially at the craniocervical junction. To our knowledge, its drug-related occurrence has not been previously reported.
Author Affiliations
From the Department of Neurology, Wilford Hall US Air Force Medical Center, Lackland Air Force Base, Tex. Dr Campbell is now with the Medical College of Georgia, Augusta.
Footnotes
Accepted for publication Feb 13, 1979.
Reprint requests to Electromyography Laboratory, Department of Neurology, Medical College of Georgia, Augusta, GA 30912 (Dr Campbell).
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