This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Edward F. Vastola, MD

Arch Neurol. 1980;37(3):150-154.

Abstract
• The constant-flow infusion method has been used to calculate conductance and the rate of CSF formation in 54 patients with varied but stable clinical pictures, normal CSF pressures, and dilated ventricles. Values for conductance varied from 0.00203 to 0.0263 mL/min/ mm H₂O, with a peak between 0.005 and 0.010, mL/min/mm H2O. Values for CSF formation uncorrected for a small, negative linear term containing the sagittal sinus pressure varied from 0.114 to 3.0 mL/min, with a peak between 0.5 and 1.0 mL/min, a range considerably larger than that given by earlier studies. Results indicate that CSF formation is reduced in the presence of low conductance. There is a possibility that the syndrome of normal pressure hydrocephalus results from underformation with ventricular stagnation. Low conductance values may identify shunt-responsive syndromes.

Author Affiliations
From the Department of Neurology and Neurosurgery, Washington University School of Medicine, St Louis.

Footnotes
Accepted for publication April 10, 1979.

Reprint requests to Neurology, Max C. Stark-loff Memorial Hospital, 1515 Lafayette Ave, St Louis, MO 63104 (Dr Vastola).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?