 |
|
Possible Role of Androgen Receptors in Amyotrophic Lateral SclerosisA Hypothesis
Leslie P. Weiner, MD
Arch Neurol. 1980;37(3):129-131.
Abstract
• Androgen receptors have been demonstrated in both cranial nerve and spinal motor neurons. This article proposes that amyotrophic lateral sclerosis (ALS) may be a disease in which androgen receptors in motor neurons are lost or not functioning. This is suggested by the male-to-4 female ratio of the disease, the age of onset, and the sparing of neurons of cranial nerves III, IV, and VI that coincidentally lack androgen receptors. The hypothesis is that ALS may be due to a loss of androgen receptors that results in an inability to respond to a variety of Insults Including axonal damage.
Author Affiliations
From the Department of Neurology, University of Southern California School of Medicine, Los Angeles.
Footnotes
Accepted for publication April 30, 1979.
Reprint requests to Department of Neurology, McKibben 142, University of Southern California, 2025 Zonal Ave, Los Angeles, CA 90033 (Dr Weiner).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
X-Linked Spinal Muscular Atrophy (Kennedy's Syndrome) A Kindred With Hypobetalipoproteinemia
Warner et al.
Arch Neurol 1990;47:1117-1120.
ABSTRACT
Protirelin (Thyrotropin-Releasing Hormone) in Amyotrophic Lateral Sclerosis: The Role of Androgens
Miller and Warnick
Arch Neurol 1989;46:330-335.
ABSTRACT
Amyotrophic Lateral Sclerosis: Recent Advances in Pathogenesis and Therapeutic Trials
Mitsumoto et al.
Arch Neurol 1988;45:189-202.
ABSTRACT
Amyotrophic Lateral Sclerosis: Lack of Central Chromatolytic Response of Motor Neurocytons Corresponding to Active Axonal Degeneration
Sobue et al.
Arch Neurol 1983;40:306-309.
ABSTRACT
Response of Patients With Amyotrophic Lateral Sclerosis to Testosterone Therapy: Endocrine Evaluation
Jones et al.
Arch Neurol 1982;39:721-722.
ABSTRACT
|
