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Immunohistochemical Studies

Inge Grundke-Iqbal, PhD; Hans Lassmann, MD; Henryk M. Wisniewski, MD, PhD

Arch Neurol. 1980;37(10):651-656.

Abstract
• The immunohistochemical staining of immunoglobulins (Ig), complement (C3), and fibrinogen in chronic relapsing experimental allergic encephalomyelitis lesions showed different staining patterns in the acute vs the chronic stage of the disease. In the acute stage, Ig, C3, and fibrinogen were present in the perivascular tissue of the brain and the spinal cord. In hyperacute-type lesions, the binding of Ig and C3 to the parenchyma was especially pronounced. The chronic stage of the disease was characterized by lg-containing cells and Ig binding to white matter in actively demyelinating lesions. Linear or granular deposits of immunoglobulin and complement, reminiscent of those described in immune complex disease, were found in the choroid plexus.

Author Affiliations
From the New York State Institute for Basic Research in Mental Retardation, New York. Dr Lassmann is now with the Neurologisches Institute, University of Vienna.

Footnotes
Accepted for publication Nov 26, 1979.

Reprint requests to New York State Institute for Basic Research in Mental Retardation, 1050 Forest Hill Rd, Staten Island, NY 10314 (Dr Grundke-Iqbal).

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ABSTRACT